Nice breakdown of the SASP mechanism. The double-whammy framing (cell retirment + immune deterioration) makes the compounding effect really clear. I've been tracking fisetin research for awhile and the strawberry angle is fascinating—people dunno that frozen berries can actually preserve these compounds better than fresh. The quercetin/onion connection is solid but the dosing from food alone probaly doesn't hit therapeutic levels for most people.
Yeah I wondered whether the effect sizes were large enough to include, as the data on quercetin intake in humans does appear mixed. I leant in the direction of introducing the hypothesis, presenting the uncertainty, then let readers come to their own judgements. I think this is a common issue with the literature regarding specific pro-longevity drugs/compounds thus far, though as research advances, hopefully statistical power will increase.
Nice breakdown of the SASP mechanism. The double-whammy framing (cell retirment + immune deterioration) makes the compounding effect really clear. I've been tracking fisetin research for awhile and the strawberry angle is fascinating—people dunno that frozen berries can actually preserve these compounds better than fresh. The quercetin/onion connection is solid but the dosing from food alone probaly doesn't hit therapeutic levels for most people.
Yeah I wondered whether the effect sizes were large enough to include, as the data on quercetin intake in humans does appear mixed. I leant in the direction of introducing the hypothesis, presenting the uncertainty, then let readers come to their own judgements. I think this is a common issue with the literature regarding specific pro-longevity drugs/compounds thus far, though as research advances, hopefully statistical power will increase.